Quarterly report pursuant to Section 13 or 15(d)

Offerings of Common Stock and Warrants and At-the-Market Offering Program (Details)

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Offerings of Common Stock and Warrants and At-the-Market Offering Program (Details) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended 46 Months Ended
Dec. 09, 2019
Dec. 08, 2019
Oct. 24, 2019
Sep. 04, 2019
Sep. 04, 2019
Feb. 04, 2019
Apr. 13, 2018
Dec. 31, 2019
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Dec. 31, 2018
Sep. 30, 2018
Dec. 31, 2019
Dec. 31, 2018
Jun. 30, 2019
Mar. 31, 2019
Jun. 07, 2018
Aug. 28, 2015
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Common stock sold (in shares)             380,625                        
Warrants exercised (in shares)     440,000                                
Exercise price (in dollars per share)     $ 0.001                                
Initial exercise price (in dollars per share)               $ 6.1200 $ 6.1200         $ 6.1200          
Common stock, par value (in dollars per share)               $ 0.001 $ 0.001         $ 0.001     $ 0.001    
Warrants, aggregate shares       440,000 440,000                            
Net proceeds from offering of common stock and warrants         $ 4,600,000                 $ 7,260,000 $ 10,948,000        
Decrease the exercise price $ 3.80 $ 8.86                                  
Additional debt discount               $ 300,000                      
Additional paid in capital               $ 300,000 $ 300,000         $ 300,000          
Exercise price of common stock (in dollars per share)               $ 3.05 $ 3.05         $ 3.05          
Issuance of warrants (in shares)                           765,000          
Aggregate offering price of common stock                 $ 1,201,000 $ 4,815,000 $ 1,222,000 $ 2,866,000 $ 3,109,000            
Aggregate registered direct offering (in shares)       580,000                              
Aggregate registered direct offering par value (in dollars per share)       $ 0.001 $ 0.001                            
Negotiated purchase price of common stock       5.00 5.00                            
Negotiated purchase price of pre-funded warrant       $ 5.0000 $ 5.0000                            
Proceeds from issuance of warrants       $ 5,100,000                              
Common warrants period                           5 years          
Percentage of common stock                           75.00%          
Deemed dividend                           $ 75,000          
June 2018 Sales Agreement                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Aggregate offering price for at-the-market offering program               $ 15,000,000 15,000,000         $ 15,000,000          
Common stock sold (in shares)               400,000           600,000          
Net proceeds from sale of the common stock, after deducting fees and other offering expenses (in dollars)                 1,200,000         $ 2,700,000          
Common stock commissions paid                 $ 41,400         $ 100,000          
June 2018 Sales Agreement | Maximum                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Aggregate offering price for at-the-market offering program                                   $ 25,000,000  
August 2015 Sales Agreement                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Common stock sold (in shares)                             300,000 2,600,000      
Net proceeds from sale of the common stock, after deducting fees and other offering expenses (in dollars)                             $ 4,000,000 $ 28,600,000      
Common stock commissions paid                             $ 100,000 $ 800,000      
August 2015 Sales Agreement | Maximum                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Aggregate offering price for at-the-market offering program                                     $ 30,000,000
Series A Warrants                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Warrants exercised (in shares)             576,000                        
Exercise price (in dollars per share)             $ 6.00                        
Outstanding warrants (in shares)               271,875 271,875         271,875          
Series A Warrants, Exercise Price 2.55                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Exercise price (in dollars per share)               $ 25.50 $ 25.50         $ 25.50          
Issued warrants (in shares)                           217,875          
Series A Warrants, Exercise Price 1.34                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Initial exercise price (in dollars per share)               $ 13.40 $ 13.40         $ 13.40          
Issued warrants (in shares)                           54,000          
Series B Warrants                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Outstanding warrants (in shares)               0 0         0          
Common Stock Warrants                                      
Offerings of Common Stock and Warrants and At-the-Market Offering Program                                      
Exercise price (in dollars per share)           $ 8.86                          
Issued warrants (in shares)                   29,654                  
Value of warrants               $ 2,300,000 $ 2,300,000         $ 2,300,000          
Warrants, aggregate shares           404,634                          
Proceeds from issuance of warrants           $ 150,000                          
Deemed dividend                   $ 74,989,000